Melinda Sheffield-Moore, PhD
301 University Boulevard
Galveston, TX 77555-0264
Phone: (409) 772-8707
Fax: (409) 772-8709
Hormone replacement, muscle metabolism
|BS (Exercise Science)||1987||Texas A&M University, College Station, Texas|
|MEd (Exercise Science)||1990||University of Houston, Houston, Texas|
|PhD (Physiology/Biology)||1997||Ball State University, Muncie, Indiana|
|Post-Doc Fellowship (Trauma and Burns)||1999||University of Texas Medical Branch|
|Post-Doc Fellowship (Metabolism)||2002||University of Texas Medical Branch|
RO1 CA127971 Sheffield-Moore (PI) 04/01/08 - 03/31/13
Nutrition and Anabolic Interventions in Cancer Cachexia (Priority score 127, awating NOGA)
The goal of this proposal is to examine whether 3 months of targeted nutritional and hormonal therapy can overcome the persistent inflammatory burden and muscle catabolism that accompanies cancer.
RO1 AG021539-05 Sheffield-Moore (PI) 09/01/03 - 5/31/08
Muscle Perfusion and Protein Metabolism in Elderly and YoungPHS 398/2590 (Rev. 09/04)
The goal of this proposal is to determine the effects of increased muscle perfusion on muscle protein synthesis in elderly, either through aerobic exercise or peripheral vasodilation both with and without amino acids.
2 M01 RR000073-43 Anderson, G (PI) 06/15/2005 – 03/31/2010
General Clinical Research Center (GCRC)
Support of clinical and translational research as the Assistant Program Director and Core Lab Director.
GlaxoSmithKline Sheffield-Moore (PI) 12/01/07-11/31/08
Quantitative Assessment of of Real-Time PCR for MuRF, Atrogin and Ubiquitin in Older Men.
The purpose of this laboratory agreement is to determine whether testosterone administration in older men alters the expression of atrogenes responsible for skeletal muscle catabolism.
R01 AG022023-01 Urban (PI) 01/01/04 – 12/30/09
Cyclic Testosterone on Muscle Function in Older Men
The goal of this project is to determine if a cycling regimen of testosterone (i.e. one month on and one month off) will enhance the normal protein anabolic effect of testosterone on skeletal muscle.
R01 AG18311-08 Volpi (PI) 09/15/00-08/31/10
Insulin and sarcopenia in the elderly
The major goals are to establish if a relative insulin resistance of muscle protein turnover is responsible for the loss of muscle with aging.