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Core Faculty

Elena Volpi, MD, PhD

Elena Volpi, MD, PhD

Elena Volpi, MD, PhD
Professor Departments of Internal Medicine and Neuroscience and Cell Biology
Director, Claude D. Pepper Older Americans Independence Center
Associate Director, Institute for Translational Sciences
Daisy Emery Allen Distinguished Chair in Geriatric Medicine


301 University Boulevard
Galveston, TX 77555-0264
Phone: (409) 772-8707
Fax: (409) 772-8709

View Dr. Volpi's bio at the Department of Internal Medicine website.

Areas of Research

Insulin sensitivity, protein synthesis

MD 1989 University of Perugia, Italy
Internship–Internal Medicine 1989 University of Perugia, Italy
Residency–Endocrinology and Diabetes 1991 University of Perugia, Italy
PhD 1995 University of Perugia, Italy


Current Funding

P30 AG024832 - National Institute on Aging
"UTMB Claude Pepper Older Americans Independence Center"
PI: E. Volpi, Director, 25% effort
Total cost: $ 5,815,268; Period: 06/01/10–04/30/15

R01 AG018311 – National Institute on Aging
"Insulin and sarcopenia in the elderly"
PI: E. Volpi, 10% effort
Total cost: $ 1,794,344; Period: 09/15/00–08/31/11

R01 AG030070 – National Institute on Aging
"Nutrition & Exercise to Improve Protein Metabolism & Prevent Sarcopenia in Aging"
PI: E. Volpi, 20% effort
Total cost: $ 2,461,946; Period: 08/01/08-05/31/14

U01 AG029824 – National Institute on Aging
"Aspirin In Reducing Events In The Elderly (ASPREE)"
PI: R.H.Grimm (Minneapolis Medical Research Foundation)
Site PI: E. Volpi, 1% effort
Site Total Cost: $ 408,000; Period: 08/06/11-01/31/17

R01 AR049877 - National Institute of Arthritis and Musculoskeletal and Skin Diseases
"Nutritional and contractile regulation of muscle growth"
PI: B.B. Rasmussen; E. Volpi, Co-I, 1% effort
Total cost: $ 2,047,156; Period: 09/01/04-08/31/14

R01 CA127971 – National Cancer Institute
"Nutrition and anabolic intervention in cancer cachexia"
PI: M. Sheffield-Moore; E. Volpi, Co-I, 1% effort
Total cost: $ 1,887,500; Period: 04/18/08-03/31/13

U54RR029876 – National Center for Research Resources
"UTMB Clinical and Translational Science Award"
PI: A. Brasier; E. Volpi, Associate Director, 31% effort
Total cost: $ 21 million; Period: 07/14/09-03/31/14

R01 AG033761 – National Institute on Aging
"Effects of amino acids on regional lipid metabolism"
PI: E. Borsheim; E. Volpi, Co-I, 2% effort
Total cost: $ 1,827,675; Period: 09/01/09-08/31/14

Select Publications

Dreyer HC, Fujita S, Glynn EL, Drummond MJ, Volpi E, Rasmussen BB. Resistance exercise increases leg muscle protein synthesis and mTOR signalling independent of sex. Acta Physiol (Oxf) 199(1):71-81, 2010.

Drummond MJ, Glynn EL, Fry CS, Timmerman KL, Volpi E, and Rasmussen BB. An increase in essential amino acid availability upregulates amino acid transporterexpression in human skeletal muscle. Am J Physiol Endocrinol Metab 298(5):E1011-8, 2010

Fry CS, Glynn EL, Drummond MJ, Timmerman KL, Fujita S, Abe T, Dhanani S, Volpi E, Rasmussen BB. Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men. J Appl Physiol 108(5):1199-209, 2010

Timmerman KL, Dreyer HC, Glynn EL, Fry CS, Sheffield-Moore M, Rasmussen BB, and Volpi E. Insulin Stimulates Human Skeletal Muscle Protein Synthesis Via an Indirect Mechanism Involving Endothelial-Dependent Vasodilation and mTORC1 Signaling. J Clin Endocrinol Metab 95: 3848–3857, 2010

Glynn EL, Fry CS, Drummond MJ, Dreyer HC, Dhanani S, Volpi E, and Rasmussen BB. Muscle protein breakdown has a minor role in the protein anabolic response to essential amino acid and carbohydrate intake following resistance exercise. Am J Physiol Regul Integr Comp Physiol 299: R533-R540, 2010

Glynn EL, Fry CS, Drummond MJ, Timmerman KL, Dhanani S, Volpi E, and Rasmussen BB. Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women. J Nutr 140(11):1970-1976, 2010.

Timmerman KL, Lee JL, Fujita S, Dhanani S, Dreyer HC, Fry CS, Sheffield-Moore M, Rasmussen BB, and Volpi E. Pharmacological vasodilation improves insulin-stimulated muscle protein anabolism but not glucose utilization in older adults. Diabetes 59(11):2764-2771, 2010.

Drummond MJ, McCarthy JJ, Sinha M, Spratt HM, Volpi E, Esser KA, and Rasmussen BB. Aging and MicroRNA Expression in Human Skeletal Muscle: A Microarray and Bioinformatics Analysis. Physiol Genomics 43:595-603, 2011.