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Elena Volpi, MD, PhD

Elena Volpi, MD, PhD

Daisy Emery Allen Distinguished Chair in Geriatric Medicine; Professor, Division of Geriatric Medicine, Department of Internal Medicine, with joint appointments in the Departments of Neuroscience and Cell Biology and Nutrition and Metabolism, Associate Director, Institute for Translational Sciences Interim Director, Sealy Center on Aging


»Visit my bio at the Sealy Center on Aging



301 University Boulevard
Galveston, TX 77555-0264
Phone: (409) 772-8707
Fax: (409) 772-8709
Email: evolpi@utmb.edu

Research Areas

Insulin sensitivity, protein synthesis


1989 MD University of Perugia, Italy
1989 Internship - Internal Medicine, University of Perugia, Italy
1991 Residency - Endocrinology and Diabetes, University of Perugia, Italy
1995 PhD, University of Perugia, Italy

Current Funding

P30 AG024832 (Volpi - PI, Director)
National Institute on Aging
UTMB Claude Pepper Older Americans Independence Center

R01 AG030070 (Volpi - PI)
National Institute on Aging
Nutrition & Exercise to Improve Protein Metabolism & Prevent Sarcopenia in Aging

U01 AG029824 (Volpi - PI)
National Institute on Aging
Aspirin In Reducing Events In The Elderly (ASPREE)
PI: R.H.Grimm (Minneapolis Medical Research Foundation)

R01 AR049877 (Rasmussen - PI)
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Nutritional and contractile regulation of muscle growth
Role: Co-Investigator

R01 AG033761(Borsheim - PI)
National Institute on Aging
Effects of amino acids on regional lipid metabolism
Role: Co-Investigator

UL1 RR029876 (Brasier - PI)
UTMB Clinical and Translational Science Award
Role: Associate Director


Selected Peer-Reviewed Publications (from > 80 publications in peer reviewed journals)

Volpi E, Kobayashi H, Mittendorfer B, Sheffield-Moore M, and Wolfe RR. Essential amino acids stimulate muscle protein anabolism in healthy older adults regardless of the presence of non-essential amino acids. Am J Clin Nutr 78:250-8, 2003. PMCID: PMC3192452

Rasmussen BB, Fujita E, Wolfe RR, Mittendorfer B, Roy M, Rowe VL, Volpi E. Protein metabolism is resistant to the anabolic action of insulin in older human skeletal muscle. FASEB J 20:768-9, 2006. PMCID: PMC2804965

Fujita S, Rasmussen BB, Cadenas JG, and Volpi E. The effect of insulin on human skeletal muscle protein synthesis is modulated by insulin-induced changes in muscle blood flow and amino acid availability. Am J Physiol Endocrinol Metab 291:E745-54, 2006. PMCID: PMC2804964

Fujita S, Rasmussen BB, Bell JA, Cadenas JG, Volpi E. Muscle intracellular amino acid kinetics in women and men. Am J Physiol Endocrinol Metab 292:77-83, 2007. PMCID: PMC2804963

Fujita S, Rasmussen BB, Cadenas JG, Drummond MJ, Glynn EL, Sattler FR, and Volpi E. Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mTOR signaling. Diabetes 56:1615–22, 2007. PMCID: PMC2740742

Volpi E, Chinkes DL, and Rasmussen BB. Sequential muscle biopsies during a six-hour tracer infusion do not affect human mixed muscle protein synthesis and muscle phenylalanine kinetics. Am J Physiol Endocrinol Metab 295(4):E959-963, 2008. PMCID: PMC2575894

Fujita S, Glynn EL, Timmerman KL, Rasmussen, BB, and Volpi E. Supraphysiological hyperinsulinemia is necessary to stimulate skeletal muscle protein anabolism in older adults: Evidence of a true age-related insulin resistance of muscle protein metabolism. Diabetologia 52:1889–1898, 2009. PMCID: PMC2843438

Timmerman KL, Dreyer HC, Glynn EL, Fry CS, Sheffield-Moore M, Rasmussen BB, and Volpi E. Insulin Stimulates Human Skeletal Muscle Protein Synthesis Via an Indirect Mechanism Involving Endothelial-Dependent Vasodilation and mTORC1 Signaling. J Clin Endocrinol Metab 95: 3848–3857, 2010. PMCID: PMC2913031

Timmerman KL, Lee JL, Fujita S, Dhanani S, Dreyer HC, Fry CS, Sheffield-Moore M, Rasmussen BB, and Volpi E. Pharmacological vasodilation improves insulin-stimulated muscle protein anabolism but not glucose utilization in older adults. Diabetes 59(11):2764-2771, 2010. PMCID: PMC2963534

Drummond MJ, Dickinson JM, Fry CS, Walker DK, Gundermann DM, Reidy PT, Timmerman KL, Markofski MM, Paddon-Jones D, Rasmussen BB, and Volpi E. Bed rest impairs muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acid ingestion in older adults. Am J Physiol Endocrinol Metab 302:(9) E1113-E1122, 2011. PMCID: PMC3361979

Timmerman KL, Dhanani S, Glynn EL, Fry CS, Drummond MJ, Jennings K, Rasmussen BB, and Volpi E. A moderate acute increase in physical activity enhances nutritive flow and the muscle protein anabolic response to mixed nutrient intake in older adults. Am J Clin Nutr 95:1403-1412, 2012. PMCID: PMC3349455