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MoTrPAC Molecular Transducers of Physical Activity Consortium

University of Texas Adult Clinical Center (UTACC)

The University of Texas Medical Branch at Galveston (UTMB) and the University of Texas Health Science Center at San Antonio (UTHSCSA) have created the University of Texas Adult Clinical Center (UTACC) for the Molecular Transducers of Physical Activity Consortium (MoTrPAC).

The primary aim of MoTrPAC is to 'extensively catalogue the biological molecules affected by physical activity in people, identify some of the key molecules that underlie the systemic effects of physical activity, and characterize the function of these key molecules. This molecular map will help us understand how physical activity translates into better health'. The consortium is composed of 6 adult clinical sites, 1 pediatric clinical center, 1 consortium coordinating center, 1 bioinformatics center, 3 preclinical animal study sites , and 7 chemical analysis sites.

UTACC is one of the Adult Clinical Sites and will be responsible for: 1) conducting exercise training trials in 450 participants in both acute and chronic exercise training studies; 2) perform physiological assessments; 3) collect biospecimens (muscle, adipose, and blood) before and after acute and chronic exercise training; and 4) analyzing and interpreting outcome data and dissemination of findings to the scientific community.

Read More

More information about participating in the exercise training trial will be posted soon.

List of All Consortium Members

Key Personnel

Principal Investigator
Blake B. Rasmussen, PhD
Principal Investigator
Nicolas Musi, MD
Recruitment and Retention Core Co-Leader
Elena Volpi, MD, PhD
Recruitment and Retention Core Co-Leader
Sara Espinoza, MD, MSc
Clinical Research Core Co-Leader
Doug Paddon-Jones, PhD
Clinical Research Core Co-Leader
Donovan Fogt, PhD
Biorepository Core Co-Leader
Christopher S. Fry, PhD
Biospecimen Management Core Co-Leader
Robin Leach, PhD
Biostatistics Core Co-Leader
Heidi Spratt, PhD
Biostatistics and Data Management Core Co-Leader
Jonathan Gelfond, MD, PhD
Darpan Patel, PhD
Douglas Cromack, MD, PhD

News & Announcements

The Exercise Antidote UTMB Collaborates with Institutions Across the U.S. to Study How Physical Activity Benefits the Body

UTMB Academic Enterprise Magazine | Summer 2017

Academic Enterprise photo

UTMB recently receives a $6.6 million grant to participate in a national project, the Molecular Tranducers of Physical Activity Consortium (MoTrPAC), which aims to better understand how physical activity improves health. Research will be conducted at 23 collaborating institutions, with an overall goal of recruiting approximately 3,000 participants in the clinical trial. MoTrPAC is the first study of it's kind, says Dr. Rasmussen: "It's never been examined on such a large scope."

Read the full article: The Exercise Antidote published in the UTMB Academic Enterprise.

UTACC-MoTrPAC Preview Day 2017

 Rehab Sciences | 05/16/17

The Center for Recovery, Physical Activity and Nutrition, a research initiative of the Division of Rehabilitation Sciences and the Department of Nutrition and Metabolism at UTMB hosted visitors from the University of Texas, San Antonio on May 15th, 2017.

Principal Investigator Blake Rasmussen, PhD, gave a presentation about the the University of Texas Adult Clinical Center (UTACC) for the Molecular Transducers of Physical Activity Consortium (MoTrPAC) and visitors toured the lab facilities. View photos of the event.